Nanomechanics of nanocapsules : mechanically triggering permeability variations of nanocapsules

Internship offer

Nanovectors such as polymer nanocapsules or lipidic nanoparticles are increasingly popular for pharmaceutical applications to transport and deliver active ingredients (small molecules, ARN for genic therapy…) to specific locations in the body. The mechanical properties of nanocapsules are expected to play a role on their flow properties in blood capillaries, on cell adhesion and internalization and hence on the whole or delivery process. However there are very few experimental studies focusing on the link between nanocapsule mechanics and delivery efficiency. This is due to the lack of experimental methods available to characterize nanocapsules mechanics and of model nanoparticles.


The goal of the project is to prepare model nanoparticles, to characterize their mechanical properties using Atomic Force Microscopy and determine whether it is possible to trigger the release of their content with a controlled deformation.

Practical details
Advisors : Cécile Monteux (cecile.monteux (arobase) espci.fr) ; Bruno Bresson (bruno.bresson (arobase) espci.fr) ; malak.alaa-eddine (arobase) espci.fr; etienne.barthel (arobase) espci.fr
We are in close contact with an international pharmaceutical group concerning this project but cannot guaranty that a funding will be obtained.

PDF - 398.3 kb
Download the document

Top



See also...

Chemical design of supramolecular micro- and macro- gels with stimuli-responsive properties in bulk and at interfaces

Proposition de stage M2 2020-2021 Laboratoire Sciences et Ingénierie de la Matière Molle, (SIMM) Adresse: ESPCI, 10 Rue Vauquelin 75005 Paris (...) 

> More...

Revêtements bio-gels pour les implants médicaux

Proposition de stage de M2 2020-2021 Laboratoire Sciences et Ingénierie de la Matière Molle, (SIMM) Adresse: ESPCI, 10 Rue Vauquelin 75005 Paris (...) 

> More...

 

Practical information

Sciences et Ingénierie de la Matière Molle

Soft Matter Enginering and Science Laboratory - UMR 7615

10 rue Vauquelin
75231 PARIS CEDEX 05
FRANCE

  • Chair : E. Barthel
  • Vice Chairs : J.B. d’Espinose & G. Ducouret
  • Administration : F. Decuq, M.-T. Mendy & M. Hirano-Courcot
  • Communication : A. Hakopian & M. Ciccotti
  • Information Technology : A. Hakopian
  • Safety, Health and Environment Assistant : F. Martin

Getting here